“Use of the Smartinhaler™ platform improved adherence to preventative medication by 180% and reduced use of reliever medication by 45% in a study of 220 children conducted over 4 years.”¹  — thelancet.com/respiratory

 

Below is a selection of peer-reviewed clinical publications arising from studies that have used the Smartinhaler™ platform:

 

Paediatric Clinical Studies

Burgess SW, Sly PD, Cooper PD, Devadason SG. Novel spacer device does not improve adherence in childhood asthma. Pediatr Pulmonol. 2007;42:736-739.
http://onlinelibrary.wiley.com/doi/10.1002/ppul.20647/abstract

 

Burgess SW, Sly PD, Morawska A, Devadason SG. Assessing adherence and factors associated with adherence in young children with asthma. Respirology. 2008;13:559-563.
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1843.2008.01292.x/abstract

 

Schultz A, Sly PD, Zhang G, Venter A, le Souëf PN, Devadason SG. Incentive device improves spacer technique but not clinical outcome in preschool children with asthma. J Paediat Child Health. 2012;48(1):52-56.
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1754.2011.02190.x/abstract

 

Schultz A, Sly PD, Zhang G, Venter A, Davadason SG, le Souëf PN. Usefulness of parental response to questions about adherence to prescribed inhaled corticosteroids in young children. Arch Dis Child. 2012;97(12):1092-1096.
http://adc.bmj.com/content/97/12/1092.long

 

Klok T, Kaptein AA, Duiverman EJ, Brand PL. High inhaled corticosteroids adherence in childhood asthma: the role of medication beliefs. Eur Respir J. 2012;40(5):1149-1155.
http://erj.ersjournals.com/content/40/5/1149.long

 

Quak W, Klok T, Kaptein AA, Duiverman EJ, Brand PL. Preschool children with high adherence to inhaled corticosteroids for asthma do not show behavioural problems. Acta Paediat. 2012;101(11);1156-1160.
http://onlinelibrary.wiley.com/doi/10.1111/j.1651-2227.2012.02805.x/abstract

 

Klok T, Kaptein AA, Duiverman EJ, Brand PL. It’s the adherence, stupid (that determines asthma control in preschool children)! Eur Respir J. 2014;43(3):783-791.
http://erj.ersjournals.com/content/43/3/783.long

 

Keemink YS, Klok T, Brand PLP. Long-term adherence to daily controller medication in children with asthma: the role of outpatient clinic visits. Pediatric Pulmonology December 2014. DOI 10.1002/ppul.23138
http://onlinelibrary.wiley.com/doi/10.1002/ppul.23138/abstract

 

Chan AHY, Stewart AWS, Harrison J, Camargo C, Black PN, Mitchell EA. The effect of an inhaler with ringtones on asthma control and school attendance in children. Lancet Respir Med. 2015;3:210-219.
http://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2815%2900008-9/abstract

 

 

 Adult Clinical Studies

 Charles T, Quinn D, Weatherall M, Aldington S, Beasley R, Holt S. An audiovisual reminder function improves adherence with inhaled corticosteroid therapy in asthma. J Allergy Clin Immunol. 2007;119:811-816.
http://www.jacionline.org/article/S0091-6749%2807%2900006-1/abstract

 

Perrin K, Williams M, Wijesinghe M, James K, Weatherall M, Beasley R. Randomized controlled trial of adherence with a single or combination inhaled corticosteroid/long-acting β-agonist inhaler therapy in asthma. J Allergy Clin Immunol. 2010;126:505-510.
http://www.sciencedirect.com/science/article/pii/S0091674910010353

 

Foster JM, Smith L, Bosnic-Anticevich SZ, Usherwood T, Sawyer SM, Rand CS, Reddel HK. Identifying patient-specific beliefs and behaviours for conversations about adherence in asthma. Int Med J. 2012;42:e136–e144.
http://onlinelibrary.wiley.com/doi/10.1111/j.1445-5994.2011.02541.x/abstract

 

Powell H, Murphy VE, Taylor DR, Hensley MJ, McCaffrey K, Giles W, et al. Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial. Lancet. 2011;378:983-990.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2811%2960971-9/abstract

 

Turton JA, Glasgow NJ, Brannan JD. Feasibility and acceptability of using bronchial hyperresponsiveness to manage asthma in primary care: a pilot study. Prim Care Respir J. 2012;21(1):28-34.
http://www.nature.com/articles/pcrj201179

 

Patel M, Pilcher J, Travers J, Perrin K, Shaw D, Black P, et al. Use of a metered-dose inhaler electronic monitoring in real-world asthma randomized controlled trial. J Allergy Clin Immunol Pract. 2013;1(1):83-91.
http://www.sciencedirect.com/science/article/pii/S2213219812000074

 

Patel M, Pilcher J, Pritchard A, Perrin K, Travers J, Shaw D, et al. Efficacy and safety of maintenance and reliever combination budesonide-formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomized controlled trial. Lancet Respir Med. 2013;1:32-42. http://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2813%2970007-9/abstract

 

Patel M, Pilcher J, Reddel HK, Pritchard A, Corin A, Helm C, et al. Metrics of salbutamol use as predictors of future adverse outcomes in asthma. Clinical & Experimental Allergy. 2013;43:1144-1151.
http://onlinelibrary.wiley.com/doi/10.1111/cea.12166/abstract

 

Patel M, Pilcher J, Munro C, Hosking A, Pritchard A, Shaw D, et al. Short-acting β-agonist use as a marker of current asthma control. J Allergy Clin Immunol Pract. 2013;1:370-377.
http://www.sciencedirect.com/science/article/pii/S2213219813002122

 

Patel M, Perrin K, Pritchard A, Williams M, Wijesinghe M, Weatherall M, et al. Accuracy of patient self-report as a measure of inhaled asthma medication use. Respirology. 2013;18:546-552.
http://onlinelibrary.wiley.com/doi/10.1111/resp.12059/abstract

 

Foster JM, Smith L, Usherwood T, Sawyer SM, Reddel HK. Inhaler reminders improve adherence with controller treatment in primary care patients with asthma. J Allergy Clin Immunol. 2014;134(6):1260-1268.e3.
http://www.jacionline.org/article/S0091-6749%2814%2900802-1/abstract

 

 

Smartinhaler™ Review Articles

Weinstein AG. The potential of asthma adherence management to enhance asthma guidelines. Ann Allergy Asthma Immunol. 2011;106:283-291.
http://www.ncbi.nlm.nih.gov/pubmed/21457876

 

Ingerski LM, Hente EA, Modi AC, Hommel KA. Electronic measurement of medication adherence in pediatric chronic illness: A review of measures. J Pediatr. 2011;159(4):528-534.
http://www.ncbi.nlm.nih.gov/pubmed/21722917

 

Boulet LP, Vervloet D, Magar Y, Foster JM. Adherence: The Goal to Control Asthma. Clin Chest Med. 2012;33:405-417.
http://www.ncbi.nlm.nih.gov/pubmed/22929091

 

Pritchard JN, Nikander K. Impact of intervention and feedback on adherence to treatment. Respiratory Drug Delivery 2012;271-282.
https://www.researchgate.net/publication/236172258_Impact_of_Intervention_and_Feedback_on_Adherence_to_Treatment

 

Chan AH, Reddel HK, Apter A, Eakin M, Riekert K, Foster JM. Adherence monitoring and e-health: How clinicians and researchers can use technology to promote inhaler adherence for asthma. J Allergy Clin Immunol Pract. 2013;1(5):446-454.
http://www.ncbi.nlm.nih.gov/pubmed/24565615

 

Morton RW, Everard ML, Elphick HE. Adherence in childhood asthma: the elephant in the room. Arch Dis Child. 2014. Downloaded from adc.bmj.com 02 June 2014 as 10.1136/archdischild-2014-306243.
http://www.ncbi.nlm.nih.gov/pubmed/24876303

 

Howard S, Lang A, Patel M, Sharples S, Shaw D. Electronic monitoring of adherence to inhaled medication in asthma. Current Respiratory Medicine Reviews. 2014;10:50-63.
http://www.ingentaconnect.com/content/ben/crmr/2014/00000010/00000001/art00011

 

Chan AH, Harrison J, Black PN, Mitchell EA, Foster JM. Using electronic monitoring devices to measure inhaler adherence: A practical guide for clinicians. J Allergy Clin Immunol Pract 2015;3:335-49.
http://www.ncbi.nlm.nih.gov/pubmed/25840665

 

1. Chan AHY, Stewart AWS, Harrison J, Camargo C, Black PN, Mitchell EA. The effect of an inhaler with ringtones on asthma control and school attendance in children. Lancet Respir Med. 2015;3:210-219
   http://www.thelancet.com/journals/lanres/article/PIIS2213-2600%2815%2900008-9/abstract